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        11-20 of 73 results for 'professor shannon simpson'

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        Research

        Upper Airway Pathology Contributes to Respiratory Symptoms in Children Born Very Preterm

        The upper airway may play a role in the respiratory symptoms experienced by some very preterm children and should be considered by clinicians ...

        Research

        Preterm birth and exercise capacity: what do we currently know?

        The long-term cardiopulmonary outcomes following preterm birth during the surfactant era remain unclear. Respiratory symptoms, particularly exertional symptoms, are common in preterm children. Therefore, cardiopulmonary exercise testing may provide insights into the pathophysiology driving exertional respiratory symptoms in those born preterm. This review aims to outline the current knowledge of cardiopulmonary exercise testing in the assessment of children born preterm in the surfactant era. ...

        Research

        Ventilatory response and stability of oxygen saturation during a hypoxic challenge in very preterm infants

        Preterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge. ...

        Research

        Inhaled corticosteroids to improve lung function in children (aged 6–12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trial

        Despite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population. ...

        Research

        Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants

        Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity. ...

        Research

        Technical standards for respiratory oscillometry

        The aim of the task force was to provide technical recommendations regarding oscillometry measurement ...

        Research

        The development and refinement of a sensitive bedside test to continually measure the severity of BPD and lung development in preterm infants

        Graham Jane Shannon Hall Pillow Simpson GL JP SS BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (Dist) MBBS, PhD (Dist) FRACP BMedSci (hons), PhD ...

        Research

        Pulmonary Gas Exchange Improves over the First Year in Preterm Infants with and without Bronchopulmonary Dysplasia

        Right shift of the peripheral oxyhaemoglobin saturation (SpO2) versus inspired oxygen pressure (PIO2) curve is a sensitive marker of pulmonary gas exchange. The aim of this study was to assess the impact of prematurity and bronchopulmonary dysplasia (BPD) on gas exchange and right-to-left shunt in the neonatal period, and its evolution over the first year of life. ...

        Research

        Clinical significance and applications of oscillometry

        Recently, "Technical standards for respiratory oscillometry" was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, quality assurance and reporting of results. Here we present a review of the clinical significance and applications of oscillometry. ...

        Research

        Persistent and progressive long-term lung disease in survivors of preterm birth

        This review aims to summarise what is known about the long-term pulmonary outcomes of contemporary preterm birth ...

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