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Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies

A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF ...

Research

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease ...

Research

The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease ...

Research

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection ...

Research

Of pigs, mice, and men: Understanding early triggers of cystic fibrosis lung disease

Understanding early triggers of Cystic Fibrosis Lung Disease ...

Research

Airway surface liquid pH is not acidic in children with cystic fibrosis

Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

Research

Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls. ...

Research

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Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

Of pigs, mice, and men: Understanding early triggers of cystic fibrosis lung disease

Airway surface liquid pH is not acidic in children with cystic fibrosis

Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

Novel end points for clinical trials in young children with cystic fibrosis

Assessment of early bronchiectasis in young children with cystic fibrosis is dependent on lung volume

Determinants of culture success in an airway epithelium sampling program of young children with cystic fibrosis