Itraconazole remains a first-line antifungal agent for certain fungal infections in children, including allergic bronchopulmonary aspergillosis (ABPA) and sporotrichosis, but poor attainment of therapeutic drug levels is frequently observed with available oral formulations. A formulation of 'SUper BioAvailability itraconazole' (SUBA-itraconazole; Lozanoc®) has been developed, with adult studies demonstrating rapid and reliable attainment of therapeutic levels, yet paediatric data are lacking. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

We have quantified the relative influence of perinatal risk factors associated with skin infection hospitalisations in WA children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

Systematic review of the treatment, prevention and public health control of skin infections in resource-limited settings where skin infections are endemic ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

We analysed the stimulation of J8 antibodies in response to infection, and the role of existing J8 antibodies in protection against subsequent infection ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Skin infections are a significant cause of severe disease, requiring hospitalization in Western Australian children, particularly with Aboriginal children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Skin infection burden in remote Aboriginal communities can be reduced by the See, Treat, Prevent (SToP skin sores and scabies) trial ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

Scabies and impetigo are common in Timor-Leste, with very high prevalence of scabies in the rural district of Ermera ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

Prevalence of impetigo (skin sores) remains high in remote Australian Aboriginal communities, Fiji, and other areas of socio-economic disadvantage. Skin sore infections, driven primarily in these settings by Group A Streptococcus (GAS) contribute substantially to the disease burden in these areas. Despite this, estimates for the force of infection, infectious period and basic reproductive ratio-all necessary for the construction of dynamic transmission models-have not been obtained. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examination of skin scrapings requires sample collection with a sharp scalpel blade, causing discomfort to patients and difficulty in children. Polymerase chain reaction (PCR)-based diagnostic assays, combined with non-invasive sampling methods, represent an attractive approach. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021