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        Research

        Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology

        The highest incidence of sepsis across all age groups occurs in neonates leading to substantial mortality and morbidity. Cardiovascular dysfunction frequently complicates neonatal sepsis including biventricular systolic and/or diastolic dysfunction, vasoregulatory failure, and pulmonary arterial hypertension. ...

        Research

        Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia

        Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. ...

        Research

        A systems biology approach to better understand human tick-borne diseases

        Tick-borne diseases are a growing global health concern. Despite extensive studies, ill-defined tick-associated pathologies remain with unknown aetiologies. Human immunological responses after tick bite, and inter-individual variations of immune-response phenotypes, are not well characterised. ...

        Research

        Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures

        Rotifers are used as the first feed for marine fish larvae and are grown in large cultures that have high loads of organic matter and heterotrophic bacteria; these bacteria are passed on to the developing fish larvae and can potentially lead to bacterial infections. ...

        Research

        Impaired Cytokine Responses to Live Staphylococcus epidermidis in Preterm Infants Precede Gram-positive, Late-onset Sepsis

        Late-onset sepsis (LOS) with Staphylococcus epidermidis is common in preterm infants, but the immunological mechanisms underlying heightened susceptibility are poorly understood. Our aim is to characterize the ontogeny of cytokine responses to live S. epidermidis in preterm infants with and without subsequent Gram-positive LOS. ...

        Research

        Plasma cytokine profiles in very preterm infants with late-onset sepsis

        Very preterm infants have a marked innate inflammatory response at the time of late-onset sepsis ...

        People

        Clinical Professor Tobias Strunk

        Head, Neonatal Health ...

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        Research

        Outcomes to 5 years of outborn versus inborn infants <32 weeks in Western Australia: A cohort study of infants born between 2005 and 2018

        We compared mortality and morbidity of inborn versus outborn very preterm infants <32 weeks' gestation in Western Australia (WA) between 2005 and 2018 ...

        Research

        Use of Neuroimaging to Predict Adverse Developmental Outcomes in High-Risk Infants

        With advances in perinatal care, we have achieved major reductions in mortality in premature and critically ill infants, but they still remain at increased risk of neurodevelopmental disability. In this context, recent advances in neuroimaging are perceived as an addition of significant value to current clinical developmental screening programs. ...

        Research

        Editorial: Immunity in Compromised Newborns

        Tobias Strunk TS MD, PhD, FRACP Head, Neonatal Health tobias.strunk@telethonkids.org.au Head, Neonatal Health Clinical Professor Tobias Strunk is a ...

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