SARS-CoV-2 infection is associated with a significant risk of hospitalisation, death, and prolonged impact on quality of life. Evaluation of new treatment options and optimising therapeutic management of people hospitalised with SARS-CoV-2 infection remains essential, but rapid changes in pandemic conditions and potential therapies have limited the utility of traditional approaches to randomised controlled trials. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Human respiratory syncytial virus (RSV) is an important cause of acute respiratory infection with the most severe disease in the young and elderly. Non-pharmaceutical interventions and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RSV globally, particularly in Australia, where during 2020 the normal winter epidemics were notably absent. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice is currently limited to in vitro, animal and observational human case-series data, with no previous randomized controlled trials (RCTs). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Impetigo is a contagious skin disease caused by Staphylococcus aureus and Streptococcus pyogenes. Without treatment, impetigo may be recurrent, develop into severe disease, or have serious, life-threatening sequelae. Standard treatment consists of topical or systemic antibiotic therapy (depending on severity), however, due to antibiotic resistance some therapies are increasingly ineffective. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Australia’s Childhood Immunisation Register (ACIR) is one of only a handful of national immunisation registers world-wide. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

We report osteomyelitis incidence in indigenous children of northern Australia is amongst the highest reported in the world ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

Scabies and impetigo infections are under-recognised and hence under-treated by clinicians ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

In 2020, school and early childhood educational centre (ECEC) closures affected over 1.5 billion school-aged children globally as part of the COVID-19 pandemic response. Attendance at school and access to ECEC is critical to a child's learning, well-being and health. School closures increase inequities by disproportionately affecting vulnerable children. Here, we summarise the role of children and adolescents in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission and that of schools and ECECs in community transmission and describe the Australian experience. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Group A Streptococcus (Strep A) is responsible for a significant global health and economic burden. The recent prioritization of Strep A vaccine development by the World Health Organization has prompted global research activities and collaborations. To progress this prioritization, establishment of robust surveillance for Strep A to generate updated regional disease burden estimates and to establish platforms for future impact evaluation is essential. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022