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        Climate change, activism, and supporting the mental health of children and young people: Perspectives from Western Australia

        The climate crisis has detrimental impacts on the mental health and wellbeing of children and young people. Psychological effects include feelings of fear, overwhelm, worry, distress, hopelessness and anger; PTSD; depression; anxiety; phobias; panic disorder; sleep disturbances; attachment disorders; learning difficulties; substance abuse; shock and trauma symptoms; adjustment problems; behavioural problems; and, suicidal thinking. ...

        Research

        A structure-function analysis of interspecies antagonism by the 2-heptyl-4-alkyl-quinolone signal molecule from Pseudomonas aeruginosa

        Here we show that antibacterial activity of 4-hydroxy-2-heptylquinoline against Vibrionaceae is species-specific ...

        Research

        Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection

        Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in humans. Accumulating clinical evidence suggests that proinflammatory interleukin (IL)-1beta signaling plays an important role in GAS disease progression. ...

        Research

        Grief and functional impairment following COVID-19 loss in a treatment-seeking sample: the mediating role of meaning

        The COVID-19 pandemic has brought unprecedented levels of grief and psychological distress in community samples. We examined unique pandemic grief risk factors, dysfunctional grief, Post-traumatic Stress Disorder symptoms, general psychiatric distress, disrupted meaning, and functional impairment in a treatment-seeking sample of people bereaved from COVID-19 in the United Kingdom. ...

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        Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: A review of the literature

        Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide... ...

        Research

        Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia

        We identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression. ...

        Research

        Is acamprosate safe to use in pregnancy, and can it mitigate the effects of alcohol consumption in pregnant mice?

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        What doctors should consider before prescribing e-liquids for e-cigarettes

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        Tonsil organ model to evaluate carriage, disease mechanisms and therapeutic interventions for treatment and prevention of GAS infections

        Tim Barnett TB PhD Head of the Strep A Pathogenesis & Diagnostics team, Deputy Head of the Wesfarmers Centre of Vaccines and Infectious Diseases 6319 ...

        Research

        LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study

        Introduction Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. ...

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