The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most commonly mutated pathways in human cancers. In particular, BRAF alterations result in constitutive activation of the rapidly accelerating fibrosarcoma-extracellular signal-regulated kinase-MAPK significant pathway, leading to cellular proliferation, survival, and dedifferentiation. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2023
• April 2023

Medulloblastoma is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Acute respiratory infections (ARI) are the most common cause of paediatric hospitalisation. There is an urgent need to address ongoing critical knowledge gaps in ARI management. The Pragmatic Adaptive Trial for Respiratory Infections in Children (PATRIC) Clinical Registry will evaluate current treatments and outcomes for ARI in a variety of paediatric patient groups. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Charlie Rebecca Christopher McLeod Pavlos Blyth CM RP CC MBBS (Hons), FRACP, PhD, DTM&H, DCH PhD, MSFS, MBBS (Hons) DCH FRACP FRCPA PhD Paediatric ...

• 1. Telethon Kids Institute
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Community reference group Clinical Trials Discover. Prevent. Cure. Contact Info This platform offers the researchers from the Wal-yan Centre a chance ...

• Wal-yan Respiratory Research Centre
• Projects
• Phage WA

The Strep A & ARF Therapeutics research team are working to accelerate research and clinical trials to improve penicillin formulation and treatment methods, to end RHD. ...

• 1. Telethon Kids Institute
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• Early Environment
• END RHD Program

The objective of this communication is to highlight the Hawthorne effect on psychobehavioral measures and the importance of a control group in clinical research, particularly for diabetes technologies ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

We found two known risk factors in a large cohort of children treated for ALL and identified other factors associated with venous thromboembolism ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Ai and Data Analytics Lead, Respiratory Research ...

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• Staff Profiles - K

Although recent clinical trials of continuous glucose monitoring (CGM) use have shown positive glycemic benefit, outcomes outside the research setting may differ and real-world studies over a long time period are limited. In April 2017, CGM was fully subsidized in Australia for people living with type 1 diabetes (T1D) <21 years. Perth Children’s Hospital is the sole pediatric diabetes center in Western Australia and is where almost all patients <18 years of age are seen. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021