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        Research

        Lessons from schools with high levels of support for students with type 1 diabetes: A qualitative study

        This project aimed to investigate how schools provide support for the psychosocial wellbeing and disease management of students with type 1 diabetes ...

        Research

        10-Valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose

        18 months of age infants receiving 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine will have higher antibody levels ...

        Research

        Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPD

        We propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes ...

        Research

        Progress in Model Systems of Cystic Fibrosis Mucosal Inflammation to Understand Aberrant Neutrophil Activity

        Here we examine the latest findings of neutrophils in pediatric CF lung disease and proposed mechanisms of their pathogenicity ...

        Research

        Associations between clusters of early life risk factors and developmental vulnerability at age 5

        This study investigated the associations between clusters of early life risk factors and developmental vulnerability in children's first year of full-time school at age 5 ...

        Research

        A comparative study of extracellular vesicle-associated and cell-free DNA and RNA for HPV detection in oropharyngeal squamous cell carcinoma

        Our study demonstrates that although HPV-DNA/RNA can be detected in EV associated DNA/RNA, cf-DNA/RNA is the more sensitive liquid biopsy medium ...

        Research

        Development of a referral pathway framework for foetal alcohol spectrum disorder in the Pilbara

        The process of referral pathway development provided a service mapping and gapping exercise to facilitate service integration ...

        Research

        Lower Cord Blood IL-17 and IL-25, but Not Other Epithelial Cell-Derived Cytokines Are Associated with Atopic Dermatitis in Infancy

        There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards "at-risk" infants. The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy. ...

        Research

        Genetics, Transcriptomics and Meta-Taxonomics in Visceral Leishmaniasis

        Visceral leishmaniasis (VL) caused by parasites of the Leishmania donovani complex can be fatal in susceptible individuals. Understanding the interactions between host and pathogen is one way to obtain leads to develop better drugs and for vaccine development. In recent years multiple omics-based approaches have assisted researchers to gain a more global picture of this interaction in leishmaniasis. Here we review results from studies using three omics-based approaches to study VL caused by L. donovani in India. ...

        Research

        Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis

        Neutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated. ...

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