To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children ...

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• 2018
• September 2018

Jean-Francois Lauzon-Joset JFLJ Senior Research Officer Jean-Francois (Jeff) Lauzon-Joset was awarded his PhD in 2014 from the Laval University ( ...

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In obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood. ...

• 1. Telethon Kids Institute
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• 2024
• April 2024

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

• 1. Telethon Kids Institute
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• 2021
• July 2021

Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

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• 2023
• December 2023

HDM allergy is associated with asthma, allergic rhinitis and atopic dermatitis. ...

• 1. Telethon Kids Institute
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• 2012
• August 2012

Almost 50 per cent of preschool children will experience at least one episode of wheeze, a whistling sound produced by the airways during breathing. ...

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• 2019
• January

Assessment of airway hyperresponsiveness are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy ...

• 1. Telethon Kids Institute
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• 2018
• November 2018

In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Read All About Lungs! Label the Lungs Paint Your Own Set of Lungs Make Your Own Slime Colouring In Build a Lung Model Lung Capacity Experiment Meet ...

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