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        Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

        Current approaches to staging chronic liver diseases have limited utility for predicting liver cancer risk. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using two distinct mouse models. ...

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        Dr Brittany Dewdney

        Postdoctoral Researcher ...

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        Research

        Silencing of TESTIN by dense biallelic promoter methylation

        Aberrant promoter DNA methylation has been reported in childhood acute lymphoblastic leukaemia and has the potential to contribute to its onset and outcome ...

        Research

        Tissue-resident memory T cells orchestrate tumour-immune equilibrium

        Our findings provide insight into the immune cell populations important for maintaining long-term tumour dormancy in peripheral tissues ...

        Research

        It is more “unbalanced” than you think

        Sébastien Malinge SM PhD Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer Council WA Fellow (CCWA), Senior ...

        Research

        Targeting DYRK1A: a key player in Down syndrome Leukaemogenesis

        Sébastien Malinge SM PhD Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer Council WA Fellow (CCWA), Senior ...

        Research

        Protocol for delivery of intraoperative immunotherapy to mice by surgical debulking of subcutaneous tumors

        Pre-clinical studies developing novel therapies to prevent cancer recurrence require appropriate surgical models. Here, we present a protocol for surgical debulking of subcutaneous tumors in mice, which allows for intraoperative application of immunotherapy-loaded biomaterials.  ...

        News & Events

        New childhood brain tumour drugs to be tested

        It is the kids he treats in his role as a paediatric oncologist that motivate Dr Nick Gottardo in his work as a Telethon Kids Institute cancer researcher. ...

        Research

        National brain tumour registry: a new era of research collaboration with China

        Cancer continues to be a leading cause of death globally. However, there remains a significant disparity in the reported incidence of cancer in developed countries, estimated to be 295.3 cases per 100,000 people, compared with only 115.7 in developing countries. Some of the reasons for this variation include lack of robust data collection with limited reporting systems, and insufficient data availability in the registries of these developing nations. ...

        News & Events

        Childhood cancers not on the rise in SA and NT, but disparity remains for Indigenous children in the NT

        Despite national and global reports of rising incidences of cancer affecting children and young people, a new analysis has found rates of childhood cancer have remained unchanged over the last 30 years in South Australia and the Northern Territory. ...

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