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        Research

        Impact of Coronavirus Disease 2019 Public Health Measures on Detections of Influenza and Respiratory Syncytial Virus in Children During the 2020 Australian Winter

        Public health measures targeting coronavirus disease 2019 have potential to impact transmission of other respiratory viruses. We found 98.0% and 99.4% reductions in respiratory syncytial virus and influenza detections, respectively, in Western Australian children through winter 2020 despite schools reopening. Border closures have likely been important in limiting external introductions. ...

        Research

        Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal Population

        Our goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians. ...

        Research

        Developmental Origins of Health and Disease (DOHaD): The importance of life-course and transgenerational approaches

        With well-established evidence that early life conditions have a profound influence on lifespan and health-span, new interventional birth cohorts are examining ways to optimise health potential of individuals and communities. These are aimed at going beyond preventing disease, to the conditions that facilitate flourishing from an early age. ...

        Research

        Exploring quality of life in individuals with a severe developmental and epileptic encephalopathy, CDKL5 Deficiency Disorder

        CDKL5 Deficiency Disorder (CDD) is a rare genetic disorder caused by a mutation in the cyclin-dependent kinase-like 5 (CDKL5) gene. It is now considered to be a developmental and epileptic encephalopathy because of the early onset of seizures in association with severe global delay. Other features include cortical visual impairment, sleep and gastro-intestinal problems. Progress in clinical understanding, especially regarding the spectrum of functional ability, seizure patterns, and other comorbidities was initially slow but accelerated in 2012 with the establishment of the International CDKL5 Database (ICDD). Our aim was to use this data source to investigate quality of life (QOL) and associated factors in this disorder. ...

        Research

        Romidepsin enhances the efficacy of cytarabine in vivo, revealing HDAC inhibition as a therapeutic strategy for KMT2A-rearranged acute lymphoblastic leukemia

        In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

        Research

        Folate pathway gene polymorphisms and risk of childhood brain tumors: Results from an Australian case-control study

        Recent research suggests that maternal folic acid supplementation is associated with a reduced risk of childhood brain tumors (CBT); polymorphisms in folate... ...

        News & Events

        International funding boost for global malaria research

        The Malaria Atlas Project (MAP) – which houses the world’s largest malaria database and is at the forefront of efforts to track and tackle the disease – has been awarded more than $16 million by the Bill & Melinda Gates Foundation. ...

        Research

        AusVaxSafety

        Christopher Peter Peter Tom Blyth Jacoby Richmond Snelling CC PJ PC T MBBS (Hons) DCH FRACP FRCPA PhD BA (Hons) MSc MBBS MRCP(UK) FRACP BMBS DTMH ...

        Research

        Targeting interventions to improve influenza control: a proof of principle geomapping study

        Christopher Kefyalew Hannah Blyth Alene Moore CC KA HC MBBS (Hons) DCH FRACP FRCPA PhD BSc, MPH, PhD OAM BSc (Hons) GradDipClinEpi PhD Director, ...

        Research

        Patient-Reported Outcome Measures for Acute Lower Respiratory Infection (ALRI-PRO): Developing and Establishing Content Validity

        Charlie Rebecca Christopher McLeod Pavlos Blyth CM RP CC MBBS (Hons), FRACP, PhD, DTM&H, DCH PhD, MSFS, MBBS (Hons) DCH FRACP FRCPA PhD Paediatric ...

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