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        Research

        Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection

        The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood. ...

        Research

        SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia

        Skin infection burden in remote Aboriginal communities can be reduced by the See, Treat, Prevent (SToP skin sores and scabies) trial ...

        Research

        Australian Aboriginal children have higher hospitalization rates for otitis media but lower surgical procedures than non-Aboriginal children

        Aboriginal children and children from lower socio-economic backgrounds were over-represented with OM-related hospitalizations but had fewer TTIs ...

        Research

        Spotting sporotrichosis skin infection: The first Australian paediatric case series

        These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting ...

        Research

        Temporal trends and socioeconomic differences in acute respiratory infection hospitalisations in children: an intercountry comparison of birth cohort studies

        Admissions for ARI were higher in Western Australia and displayed greater socioeconomic disparities than England and Scotland, where ARI rates are increasing ...

        Research

        Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma

        We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

        Research

        Research Note: Adaptive trials

        This Research Note has explored the strengths, risks and potential complexity of adaptive trials ...

        Research

        Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model

        Here we investigate these features in an animal model related to autism spectrum disorder - the DVD-deficient rat ...

        Research

        Influenza vaccine effectiveness in preventing influenza-associated hospitalizations during pregnancy: A multi-country retrospective test negative design study, 2010–2016

        Between 2010 and 2016, influenza vaccines offered moderate protection against laboratory-confirmed influenza-associated hospitalizations during pregnancy ...

        Research

        Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting

        Occult maternal heart disease may be responsible for a substantial proportion of adverse pregnancy outcomes in low-resource settings ...

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