A systematic review of current evidence using various electronic databases was conducted. Studies were appraised using a recognised clinical appraisal tool. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

The pattern of association between socioeconomic factors and health outcomes has primarily depicted better health for those who are higher in the social... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• November 2011

Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Rishi Sury Laurence Sébastien Kotecha Cheung Malinge RS LC SM MB ChB (Hons) MRCPCH FRACP PhD BPharm (Hons) MBA PhD PhD Co-Head, Leukaemia ...

• 1. Telethon Kids Institute
• Projects

Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphoblastic leukemia (T-ALL) mainly occurs at promoters of Polycomb Repressor Complex 2 (PRC2) target genes that are not expressed in normal or malignant T-cells and which display a reciprocal association with H3K27me3 binding. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

Vanessa Timo Fear Lassmann VF T BSc (Hons), PhD BSc (Hons) MSc PhD Head, Translational Genetics Team Feilman Fellow; Program Head, Precision Health ...

• 1. Telethon Kids Institute
• Projects

Timo Lassmann T BSc (Hons) MSc PhD Feilman Fellow; Program Head, Precision Health and Team Lead, Computational Biology timo.lassmann@ ...

• 1. Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Precision Health
• Computational Biology

In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

B lymphopoiesis is characterized by progressive loss of multipotent potential in hematopoi-etic stem cells, followed by commitment to differentiate into B cells, which mediate the humoral response of the adaptive immune system. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022