Pathogen strain diversity is an important driver of the trajectory of epidemics. The role of bioclimatic factors on the spatial distribution of dengue virus serotypes has, however, not been previously studied. Hence, we developed municipality-scale environmental suitability maps for the four dengue virus serotypes using maximum entropy modeling. ...

• 1. Telethon Kids Institute
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• 2023
• December 2023

Telomeres are long hexamer (TTAGGG) repeats at the ends of chromosomes, and contribute to maintenance of chromosomal stability. ...

• 1. Telethon Kids Institute
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• 2015
• January 2015

Research continues to highlight that there are unacceptable numbers of avoidable (preventable and treatable) deaths in early life in ...

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Publications, papers and findings coming out of The ORIGINS Project and its sub-projects ...

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Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 antagonist and ClpP agonist that has shown preclinical and emerging clinical efficacy in DMG.  ...

• 1. Telethon Kids Institute
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• 2023
• May 2023

In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to... ...

• 1. Telethon Kids Institute
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• 2014
• March 2014

The proportion of 25(OH)D3 that undergoes epimerization is greater with oral vitamin D3 supplementation than exposure to UVR in mice, but not in humans ...

• 1. Telethon Kids Institute
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• 2019
• February 2019

In this rhinovirus study, we first hypothesized that ex vivo human cells response to virus can serve as a proxy for otherwise controversial in vivo human... ...

• 1. Telethon Kids Institute
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• 2015
• June 2015

The spatial and temporal variability inherent in malaria transmission within countries implies that targeted interventions for malaria control in high-burden settings and subnational elimination are a practical necessity. Identifying the spatio-temporal incidence, risk, and trends at different administrative geographies within malaria-endemic countries and monitoring them in near real-time as change occurs is crucial for developing and introducing cost-effective, subnational control and elimination intervention strategies. ...

• 1. Telethon Kids Institute
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• 2022
• July 2022

AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment. ...

• 1. Telethon Kids Institute
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• 2012
• January 2012