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        Research

        Targeting DYRK1A: a key player in Down syndrome Leukaemogenesis

        Sébastien Malinge SM PhD Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer Council WA Fellow (CCWA), Senior ...

        Research

        Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used

        Surgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is common, with a relapse rate of around 45% for non-small cell lung cancer. The tumour draining lymph nodes (dLN) are resected at the time of surgery for staging purposes, and this cannot be a null event for patient survival and future response to immune checkpoint blockade treatment. This project investigates cancer surgery, lymphadenectomy, onset of metastatic disease, and response to immunotherapy in a novel model that closely reflects the clinical setting. In a murine metastatic lung cancer model, primary subcutaneous tumours were resected with associated dLNs remaining intact, completely resected or partially resected. ...

        News & Events

        Funding boost to melanoma research

        A Telethon Kids Institute researcher will investigate new ways to harness the body’s own immune system to fight melanoma, thanks to Cancer Council WA funding. ...

        Postdoctoral Research Associate - Brain Tumour Research

        The Opportunity The Brain Tumour Research Program is a collaborative group composed of clinical and lab-based researchers focused on the goal of ...

        People

        Dr Sébastien Malinge

        Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer Council WA Fellow (CCWA), Senior Research Fellow (UWA), University Associate (Curtin) ...

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        News & Events

        Farewelling Jette Ford – a Telethon Kids legend

        The Telethon Kids Institute has farewelled one of its most treasured employees, with research officer Jette Ford closing the door on a quietly stellar 37-year career which has changed the face of cancer research in WA and around the world. ...

        Research

        Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

        Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and re ...

        Research

        Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism

        We examined the baseline profile of a panel of T-ALL cell lines to determine factors that contribute to GC resistance without prior drug selection. ...

        Research

        Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

        In this review we explore the current literature about the predictive characteristics of the tumor microenvironment and discuss therapeutic approaches ...

        Research

        Novel therapeutics approaches for infants with high-risk infant acute lymphoblastic leukaemia

        Rishi Sury Laurence Sébastien Kotecha Cheung Malinge RS LC SM MB ChB (Hons) MRCPCH FRACP PhD BPharm (Hons) MBA PhD PhD Co-Head, Leukaemia ...

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