Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mitochondrial proteomes.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome requires separate enzymatic activities that can sterically compete, suggesting a life-long trade-off between these two processes. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular mechanisms that lead to chemoresistance traits of ST-RELA remain elusive. The aim of this study was to assess RELA fusion-dependent signaling modules, specifically the role of the Hedgehog (Hh) pathway as a novel targetable vulnerability in ST-RELA. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Lung abscess is a rare condition in paediatrics with a paucity of literature. Intravenous antibiotics is the main therapy; however interventional radiological approaches have led to the use of percutaneous drainage. Surgery is reserved for the management of complications. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

Bronchiectasis, particularly in children, is an increasingly recognised yet neglected chronic lung disorder affecting individuals in both low-to-middle and high-income countries. It has a high disease burden and there is substantial inequity within and between settings. Furthermore, compared with other chronic lung diseases, considerably fewer resources are available for children with bronchiectasis.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• March 2024

Tuberculosis (TB) remains a global public health challenge, causing substantial mortality and morbidity. While TB treatment has made significant progress, it often leaves survivors with post-TB sequelae, resulting in long-term health issues. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

Group A Streptococcus (GAS) is a major human pathogen responsible for superficial infections through to life-threatening invasive disease and the autoimmune sequelae acute rheumatic fever (ARF). Despite a significant global economic and health burden, there is no licensed vaccine available to prevent GAS disease. Several pre-clinical vaccines that target conserved GAS antigens are in development. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Methodological issues and implications for interventions to support young Aboriginal people's adaptation are discussed. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• October 2013

Learn about those behind the LiLO research study ...

• Telethon Kids Institute
• Projects
• Language in Little Ones

This is a rare examination of joblessness over 3 succeeding generations and its onward effects upon children, and is one of the few in the research literature. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013