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        Research

        Chemical analysis of new and “aged” e-liquids: Development of a rapid toxicological screening approach

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        Lung function in a model of a paediatric metabolic disease

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study

        Introduction Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. ...

        Research

        Respiratory impedance in healthy unsedated South African infants: Effects of maternal smoking

        Non-invasive techniques for measuring lung mechanics in infants are needed for a better understanding of lung growth and function... ...

        Research

        Determining whether ion-channels influence the response to brain cancer therapeutics

        Terrance Brittany Johns Dewdney T BD BSc, MBSc, PhD Honorary Research Associate Postdoctoral Researcher - Oncogenic Signalling Laboratory ...

        Research

        Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

        Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

        Research

        Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

        Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

        Research

        Public stigma toward prolonged grief and COVID-19 bereavement: A vignette-based experiment

        We investigated the effects of cause of death and the presence of prolonged grief disorder on eliciting public stigma toward the bereaved. ...

        People

        Vincent Mancini

        Senior Research Fellow ...

        08 6319 9464 Email me LinkedIn
        Research

        Silver Russel syndrome in an aboriginal patient from Australia

        We report a 4-year-old Australian Aboriginal girl who was born at 32 weeks gestation with features strongly suggestive of Silver-Russell syndrome ...

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