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        211-220 of 1000 results for 'cancer'

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        News & Events

        Childhood cancers not on the rise in SA and NT, but disparity remains for Indigenous children in the NT

        Despite national and global reports of rising incidences of cancer affecting children and young people, a new analysis has found rates of childhood cancer have remained unchanged over the last 30 years in South Australia and the Northern Territory. ...

        Research

        Incidence and survival for childhood central nervous system tumours in Australia, 1983–2016

        To investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade. Methods: National, population-based data on all children under 15 years old diagnosed with a CNS tumour between 1983 and 2016 were sourced from the Australian Childhood Cancer Registry. Incidence rate trends were calculated using Joinpoint regression. ...

        News & Events

        Funding boost to melanoma research

        A Telethon Kids Institute researcher will investigate new ways to harness the body’s own immune system to fight melanoma, thanks to Cancer Council WA funding. ...

        Research

        The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program

        Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled ETO2 depletion models. We demonstrate that beyond its well-established repressive activity, ETO2 directly activates transcription of MYB, among other genes. ...

        News & Events

        Farewelling Jette Ford – a Telethon Kids legend

        The Telethon Kids Institute has farewelled one of its most treasured employees, with research officer Jette Ford closing the door on a quietly stellar 37-year career which has changed the face of cancer research in WA and around the world. ...

        Research

        Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2

        In T-cell acute lymphoblastic leukemia (T-ALL) cytogenetic alterations juxtapose the LIM-domain-only-2 gene (LMO2) with T-cell receptor loci. ...

        News & Events

        Precision medicine offering new hope for kids with aggressive cancers

        A world-first study involving more than 100 cancer researchers and clinicians across Australia – including from Telethon Kids Institute and Perth Children’s Hospital – has shown that precision medicine can significantly improve outcomes for children with high-risk cancer. ...

        Focus Area

        Chronic and Severe Diseases

        The Chronic and Severe Diseases research theme consists of five programs: Diabetes, Metabolism and Clinical Sciences, Cancer, Perioperative Care, Precision Health, and Respiratory Health. ...

        Research

        Imaging of pediatric brain tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee/ASPNR White Paper

        Tumors of the central nervous system are the most common solid malignancies in children and the most common cause of pediatric cancer-related mortality. Imaging plays a central role in diagnosis, staging, treatment planning, and response assessment of pediatric brain tumors. ...

        Research

        A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

        Here we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia ...

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