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        Research

        Investigating disparity in access to Australian clinical genetic health services for Aboriginal and Torres Strait Islander people

        Globally, there is a recognised need that all populations should be able to access the benefits of genomics and precision medicine. However, achieving this remains constrained by a paucity of data that quantifies access to clinical genomics, particularly amongst Indigenous populations. ...

        Research

        Gender-Neutral Toilets: A Qualitative Exploration of Inclusive School Environments for Sexuality and Gender Diverse Youth in Western Australia

        School toilets have been identified by sexuality and gender diverse (SGD) students as the least safe spaces in educational institutions. They are sites of verbal, physical and sexual victimisation. ...

        Research

        The immunogenetic impact of European colonization in the Americas

        The introduction of pathogens originating from Eurasia into the Americas during early European contact has been associated with high mortality rates among Indigenous peoples, likely contributing to their historical and precipitous population decline. ...

        Research

        Devising a Missing Data Rule for a Quality of Life Questionnaire - A Simulation Study

        The aim of this study was to devise an evidence-based missing data rule for the Quality of Life Inventory-Disability (QI-Disability) questionnaire specifying how many missing items are permissible for domain and total scores to be calculated using simple imputation. ...

        Research

        Gender differences in time allocation contribute to differences in developmental outcomes in children and adolescents

        Using over 50 thousand time-use diaries from two cohorts of children, we document significant gender differences in time allocation in the first 16 years in life. Relative to males, females spend more time on personal care, chores and educational activities and less time on physical and media related activities. These gender gaps in time allocation appear at very young ages and widen overtime. ...

        Research

        Impact of previous exposure to SARS-CoV-2 and of S-Trimer (SCB-2019) COVID-19 vaccination on the risk of reinfection: a randomised, double-blinded, placebo-controlled, phase 2 and 3 trial

        We previously reported the efficacy of the adjuvanted-protein COVID-19 vaccine candidate S-Trimer (SCB-2019) in adults who showed no evidence of previous exposure to SARS-CoV-2. In this study, we aimed to investigate the extent of protection afforded by previous exposure to SARS-CoV-2 on subsequent COVID-19 infection, as well as the efficacy, safety, and reactogenicity of SCB-2019 in participants who were enrolled in the Study. ...

        Research

        Experience of patients with lung cancer and with targeted therapy-related skin adverse drug reactions: A qualitative study

        To explore the experience of non-small-cell lung cancer patients with targeted therapy-related skin adverse drug reactions. ...

        Research

        Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action

        Chemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited. ...

        Research

        The effect of iron deficiency on quality of life outcomes after surgery for obstructive sleep apnoea

        This study aimed to assess the effect of iron deficiency on parent-reported changes in quality of life (QOL) among children receiving an adenotonsillectomy for paediatric obstructive sleep apnoea (OSA). ...

        Research

        What Works for Whom in School-Based Anti-bullying Interventions? An Individual Participant Data Meta-analysis

        The prevalence of bullying worldwide is high (UNESCO, 2018). Over the past decades, many anti-bullying interventions have been developed to remediate this problem. However, we lack insight into for whom these interventions work and what individual intervention components drive the total intervention effects. ...

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