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        Research

        Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

        The Human Phenotype Ontology is a standardized vocabulary of phenotypic abnormalities used by researchers, clinicians, informaticians and electronic health record systems ...

        Research

        Adjunctive protein synthesis inhibitor antibiotics for toxin suppression in Staphylococcus aureus infections: a systematic appraisal

        A summary of the literature regarding the use of adjunctive protein synthesis inhibitors for toxin suppression in the setting of S. aureus infections is presented ...

        Research

        A novel, palatable paediatric oral formulation of midazolam: Pharmacokinetics, tolerability, efficacy and safety

        We conclude that the novel chocolate-based formulation of midazolam provides improved tolerability while remaining efficacious ...

        Research

        Predicting respiratory hospital admissions in young people with cerebral palsy

        Most risk factors for respiratory hospital admissions in young people with cerebral palsy are potentially modifiable ...

        Research

        New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment

        We provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL ...

        Research

        Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

        Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target ...

        Research

        ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

        Assessment of airway hyperresponsiveness are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy ...

        Research

        A group randomized controlled trial evaluating parent involvement in whole-school actions to reduce bullying

        Whole-school capacity-building intervention in early and middle childhood can improve the likelihood and frequency of positive parent–child communication about bullying ...

        Research

        Research priority setting in childhood chronic disease: a systematic review

        Research priority setting activities in paediatric chronic disease cover many discipline areas and have elicited a broad range of topics ...

        Research

        Association between male genital anomalies and adult male reproductive disorders: a population-based data linkage study spanning more than 40 years

        We provide new evidence to support current guidelines for orchidopexy before age 18 months to decrease the risk of future testicular cancer and infertility ...

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