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        231-240 of 1980 results for 'Council'

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        Research

        Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients

        Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. ...

        Research

        Organization and expression of the mammalian mitochondrial genome

        The mitochondrial genome encodes core subunits of the respiratory chain that drives oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in high-throughput sequencing technologies and cryoelectron microscopy have shed light on the structure and organization of the mitochondrial genome and revealed unique mechanisms of mitochondrial gene regulation. ...

        Research

        Fidelity and coordination of mitochondrial protein synthesis in health and disease

        The evolutionary acquisition of mitochondria has given rise to the diversity of eukaryotic life. Mitochondria have retained their ancestral α-proteobacterial traits through the maintenance of double membranes and their own circular genome. Their genome varies in size from very large in plants to the smallest in animals and their parasites. The mitochondrial genome encodes essential genes for protein synthesis and has to coordinate its expression with the nuclear genome from which it sources most of the proteins required for mitochondrial biogenesis and function. ...

        Research

        A surveillance clinic for children and adolescents with, or at risk of, hereditary cancer predisposition syndromes

        Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation. ...

        Research

        Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

        The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations. ...

        Research

        Gender, Culture and Intervention: Exploring Differences between Aboriginal and Non-Aboriginal Children's Responses to an Early Intervention Programme

        Evaluation of a group parenting programme in the Northern Territory of Australia showed significant differences in benefits for Aboriginal and non-Aboriginal... ...

        Research

        Mental health problems among young people on remand: has anything changed since 1989?

        To determine whether the prevalence of mental health problems among adolescents on court ordered remand in South Australia has changed since 1989 ...

        Research

        Preschool psychopathology reported by parents in 23 societies: testing the seven-syndrome model of the child behavior checklist for ages 1.5-5.

        To test the fit of a seven-syndrome model to ratings of preschoolers' problems by parents in very diverse societies. ...

        Research

        Nothing but fear itself: parental fear as a determinant of child physical activity and independent mobility

        Over the past decade we have seen declining rates in child engagement in physical activity with escalating health problems ensuing. ...

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