Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations. ...

• Telethon Kids Institute
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• 2022
• July 2022

Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. ...

• Telethon Kids Institute
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• 2021
• July 2021

Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are... ...

• Telethon Kids Institute
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• Reports and Findings
• 2015
• May 2015

Rare childhood cancers have not benefited to the same extent from the gains that have been made for their frequently occurring counterparts. ...

• Telethon Kids Institute
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• Reports and Findings
• 2015
• February 2015

Senior Research Fellow ...

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The ANZCHOG-BN is a new biobank network in Australasia that was developed to improve and streamline access to high-quality pediatric and AYA cancer biospecimens ...

• Telethon Kids Institute
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• 2019
• April 2019

Avantogen Limited (ACU:ASX) today announced that cancer researchers at Perth's Telethon Institute for Child Health Research (TICHR) and Avantogen Limited ...

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• 2005
• October

Alison Linda W. Joost Omar McDonnell Wijaya Lesterhuis Elaskalani AM LW WJL OE BSc (Hons), PhD BSc PhD BSc, MSc, PhD Early Career Fellow Postdoctoral ...

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Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

• Telethon Kids Institute
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• Reports and Findings
• 2021
• April 2021

Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

• Telethon Kids Institute
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• Reports and Findings
• 2018
• August 2018