Epidemiological studies have demonstrated that survivors of acute burn trauma are at long-term increased risk of developing a range of morbidities. The mechanisms underlying this increased risk remain unknown. This study aimed to determine whether burn injury leads to sustained immune dysfunction that may underpin long-term morbidity. Plasma and peripheral blood mononuclear cells were collected from 36 pediatric burn survivors >3 years after a non-severe burn injury (<10% total body surface area) and from age/sex-matched non-injured controls. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children during acute virus-associated exacerbations and later during convalescence. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

Pamela André Matt Laird Schultz Cooper PL AS MC Pictured (left to right) are the team working on the ACE project in the Pilbara region Darcy Roe - ...

• Telethon Kids Institute
• Projects

Researchers from the Telethon Institute have today been awarded $3.46 million in competitive grants and two early career fellowships from the NHMRC. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2012
• October

This chapter reviews the prevalence, characteristics, and clinical management of orthopedic problems in RTT. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

Prenatal alcohol exposure is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing evidence for a potential mechanistic link to Fetal Alcohol Spectrum Disorder. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PApilloma TRIal against Cancer In young Adults. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Our findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

Despite national and global reports of rising incidences of cancer affecting children and young people, a new analysis has found rates of childhood cancer have remained unchanged over the last 30 years in South Australia and the Northern Territory. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2024
• June

The objective was to determine the association between maternal serum 25(OH)-vitamin D concentrations and behavioural, emotional and language outcomes... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• March 2012