We provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Evidence for the existence of additional regulatory mechanisms of the expression of neurodegenerative disease-causing genes by antisense long noncoding RNAs ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

The immediate-early response mediates cell fate in response to a variety of extracellular stimuli and is dysregulated in many cancers. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

Government reports 2018 Pathways of young people in contact with multiple government agencies in Western Australia. Sims S, Maclean M, Hansen M, ...

• 1. Telethon Kids Institute
• Projects
• Developmental Pathways Project
• Research outputs

The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-term side effects in survivors. This study aims to identify more effective and safer therapeutics for these patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Overweight and obese children reported greater psychosocial distress than healthy weight children, and these differences were more pronounced for girls than boys. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

Examining the overlap between genes perturbed in the KD-CAGE experiments and genes with a ChIP-seq peak within 50 kb of their promoter, we identified direct... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

The need to target prevention and intervention efforts for childhood overweight and obesity towards families with overweight parents ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• November 2016

With more than one in four Australian children overweight or obese, and the significant risks this poses for health problems like asthma, depression,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013