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        251-260 of 1005 results for 'CANCER'

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        Research

        Estimation of quantitative levels of diesel exhaust exposure and the health impact in the contemporary Australian mining industry

        To estimate the levels of exposure to diesel exhaust expressed by EC in the mining industry and to describe the risk of lung cancer that may result from it. ...

        Research

        Developing new immune based therapies for neuroblastoma

        Alison Linda W. Joost Omar McDonnell Wijaya Lesterhuis Elaskalani AM LW WJL OE BSc (Hons), PhD BSc PhD BSc, MSc, PhD Early Career Fellow Postdoctoral ...

        Research

        In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma

        Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients. ...

        Research

        MK2 inhibition induces p53-dependent senescence in glioblastoma cells

        In response to DNA damaging chemotherapy, targeting MK2 in p53-mutated cells produces a phenotype that is distinct from the p53-deficient phenotype ...

        Research

        Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth

        Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. ...

        Research

        Accumulation of CD103+ CD8+ T cells in a cutaneous melanoma micrometastasis

        Results support the emerging concept that CD103+ CD8+ tissue‐resident memory T cells are key mediators of cancer surveillance ...

        Research

        Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells

        Human embryonic stem cell-derived neural stem cells (hESC-NSCs) are an attractive cell type for studying ...

        Sarcoma Translational Research

        We think all kids with Sarcoma should be able to lead happy, healthy lives! To achieve this, we aim to discover and develop safer and more effective treatments by doing inventive and rigorous research. We focus on addressing high relapse rates using a combination of unique pre-clinical models, patient samples and systems immunology. ...

        Research

        Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

        These findings implicate the activation of STAT3 as one pathway that may mediate resistance to IGF-II-targeted therapy in HCC ...

        Research

        LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study

        Introduction Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. ...

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