Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

In response to DNA damaging chemotherapy, targeting MK2 in p53-mutated cells produces a phenotype that is distinct from the p53-deficient phenotype ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

We think all kids with Sarcoma should be able to lead happy, healthy lives! To achieve this, we aim to discover and develop safer and more effective treatments by doing inventive and rigorous research. We focus on addressing high relapse rates using a combination of unique pre-clinical models, patient samples and systems immunology. ...

• Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Cancer Program

Results support the emerging concept that CD103+ CD8+ tissue‐resident memory T cells are key mediators of cancer surveillance ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Human embryonic stem cell-derived neural stem cells (hESC-NSCs) are an attractive cell type for studying ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

Whole genome sequencing of poor and exceptional survivors identified a gain in Chromosome 19 that was exclusive to the exceptional survivors ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• September 2011

Our results show that TRM cells have a fundamental role in the surveillance of subclinical melanomas in the skin by maintaining cancer-immune equilibrium ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019