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        Research

        BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency Granulopoiesis

        Bacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100 years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well as pathogen-agnostic (other infections, autoimmunity, allergies, and cancer) effects. ...

        Research

        Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

        We identified new asthma loci, found new associations at loci implicated in the comorbidity of asthma plus hay fever and confirmed nine known loci. ...

        Research

        Analysis of IgE binding patterns to house dust mite allergens in scabies-endemic communities: insights for both diseases

        This study analysed the IgE binding patterns caused by house dust mite allergens in scabies endemic communities in Australia. ...

        Research

        Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

        Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function ...

        Research

        Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma

        Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells. ...

        Research

        Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and C

        Our results indicate a dissociation between the antibody and T-cell responses to rhinoviruses ...

        Research

        Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniae

        Delayed development of antibodies to S. pneumoniae in infancy is associated with the development of atopy and asthma. ...

        Research

        The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

        Lung inflammation resulting from ARIs during infancy is linked to asthma development. ...

        Research

        Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.

        Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity ...

        Research

        Prediction of peri-operative adverse respiratory events in children: The role of exhaled nitric oxide.

        Increased levels of exhaled nitric oxide (eNO) may be a more objective predictor in identifying children at higher risk of peri-operative adverse respiratory... ...

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