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        261-270 of 1005 results for 'CANCER'

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        A tight circle of support - the family and friends of Ethan Davies

        Children with brain cancers don't need soft toys; their parents don't need platitudes. They need answers. Options. Smarter, safer treatments. Hope. ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        A novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

        Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

        Research

        Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

        Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

        Research

        Australian Study of Causes of Acute Lymphoblastic Leukaemia in Children

        Liz Carol Ursula Milne Bower Kees E C UR MPH PhD MBBS MSc PhD FAFPHM DLSHTM FPHA PhD Honorary Emeritus Fellow Senior Principal Research Fellow, ...

        Research

        Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic

        Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare. ...

        Research

        Parental occupational exposure to engine exhausts and childhood brain tumors

        Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. ...

        Research

        Therapeutic opportunities from dissecting the pre-B leukaemia bone marrow microenvironment

        Laurence Rishi Sury Sébastien Cheung Kotecha Malinge LC RS SM BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD PhD Co-Head, Leukaemia ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study

        DNA methylation array profiling for classifying pediatric central nervous system (CNS) tumors is a valuable adjunct to histopathology. However, unbiased prospective and interlaboratory validation studies have been lacking. The AIM BRAIN diagnostic trial involving 11 pediatric cancer centers in Australia and New Zealand. ...

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