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        271-280 of 1005 results for 'CANCER'

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        Research

        Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic

        Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare. ...

        Research

        Parental occupational exposure to engine exhausts and childhood brain tumors

        Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. ...

        Research

        Therapeutic opportunities from dissecting the pre-B leukaemia bone marrow microenvironment

        Laurence Rishi Sury Sébastien Cheung Kotecha Malinge LC RS SM BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD PhD Co-Head, Leukaemia ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Verschlimmbesserung: Craniospinal Radiotherapy Is Essential in WNT Medulloblastoma Patients

        Standard-risk WNT medulloblastoma patients have an excellent prognosis using the combination of standard dose craniospinal radiotherapy (CSI) followed by platinum and alkylator based chemotherapy. A recent pilot study that attempted to completely omit radiotherapy was terminated early as all patients relapsed rapidly. The study highlights that therapy is the most important prognostic factor, with CSI still required to cure even the most favorable subgroup of medulloblastoma patients.  ...

        Research

        Setonix Pharmaceuticals: Enhancing immuno-oncology with small molecule drugs

        Team Associate Professor W. Joost Lesterhuis Director Email Associate Professor Matt Piggott Director Email Dr Alma Fulurija Director Email Dr Louis ...

        Research

        ErbB4 in the brain: Focus on high grade glioma

        The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTKs) consists of EGFR, ErbB2, ErbB3, and ErbB4. These receptors play key roles in cell proliferation, angiogenesis, cell migration, and in some cases, tumor promotion. ...

        Research

        Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

        Cancer immunotherapy has shown impressive results, but most patients do not respond. ...

        Research

        The role of voltage-gated sodium channels in high grade glioma

        Emily Terrance Anya Brittany Fletcher Johns Jones Dewdney EF T AJ BD BSc (Hons) MRes PhD BSc MSc PhD BSc, MBSc, PhD Senior Research Fellow Honorary ...

        Research

        Germline Elongator mutations in Sonic Hedgehog medulloblastoma

        Genetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers ...

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