This prerandomization analysis from the Australian HCL-Adult trial (registration number: ACTRN12617000520336) compared masked continuous glucose monitoring (CGM) metrics among adults using insulin pumps versus multiple daily injections (MDIs), who were all self-monitoring blood glucose (SMBG). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Hybrid closed-loop (HCL) therapy has improved glycemic control in children and adolescents with type 1 diabetes; however, the efficacy of HCL on glycemic and psychosocial outcomes has not yet been established in a long-term randomized clinical trial. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

CGM with remote monitoring was found to improve multiple measures of quality of life, reduce family stress, and improve parental sleep ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• December 2018

Android-HCLS in both adults and adolescents reduced nocturnal hypoglycemia and, in adults, improved overnight time in target range and treatment satisfaction ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity ...

• 1. Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Diabetes, Metabolism and Clinical Sciences
• Diabetes and Obesity Research
• Expired Projects

These observations suggest factors in the modern environment promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

To determine whether continuous subcutaneous insulin infusion (CSII) vs. multiple daily injections (MDI) therapy from near-diagnosis of type 1 diabetes is associated with reduced glycaemic variability (GV) and altered microRNA (miRNAs) expression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial and observational cohort study, we characterized the progression of vascular phenotypes throughout this important period and investigated the effect of ACE (angiotensin-converting enzyme) inhibitors and statins in high-risk adolescents. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

These findings present an opportunity to move towards the personalized care of adolescents with type 1 diabetes mellitus ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

We report an overall good adherence to ACE inhibitors and statins during a clinical trial, although there was a clear decline in adherence over time ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020