Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive features. Here, we employed single-cell RNA sequencing, spatial transcriptomics and bulk RNA sequencing to delineate specific cell subsets involved in hepatocellular carcinoma  relapse and response to immunotherapy.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Airway inflammation and infection are present from early in life, often before children are symptomatic. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• March 2015

Inclusion of early child development in the United Nations Sustainable Development Agenda raises issues of how this goal should be monitored, particularly in low resource settings. The aim of this paper was to explore the validity of the early Human Capability Index (eHCI); a population measure designed to capture the holistic development of children aged 3-5 years. Convergent, divergent, discriminant and concurrent validity were examined by exploring the associations between eHCI domains and child (sex, age, stunting status, preschool attendance) and family (maternal education, home learning environment) characteristics. Analyses were repeated using data from seven low and middle income countries. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Since 1990 mortality for those with severe cerebral palsy in Western Australia has tended to shift from childhood to early adulthood ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

The period of infancy and early childhood is a critical time for interventions to prevent future mental health problems. The first signs of mental health difficulties can be manifest in infancy, emphasizing the importance of understanding and identifying both protective and risk factors in pregnancy and the early postnatal period. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Yasmin Alanna Harman-Smith Sincovich YHS AS BA, BHlthSc(Hons), PhD BPsych(Hons), PhD Head, Early Years Systems Evidence; Head, Tenders Support Unit ...

• 1. Telethon Kids Institute
• Projects
• Past projects

Amy Bec Finlay-Jones Young AFJ BY BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) BSc Nursing, Grad Cert Clinical Nursing, M Mental ...

• 1. Telethon Kids Institute
• Projects

Evaluating early childhood education in the villages of Northern Laos Northern Laos is a challenging place to run an education system. The ...

• 1. Telethon Kids Institute
• Our research
• Research Impact
• 2021
• Research translation

Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

This study investigated where preschool children were more or less active in outdoor play areas in Early Childhood Education and Care (ECEC) centers using a novel method of combined device-measured physical activity, spatial data and on-site audit data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022