Our findings highlight the potential of salinomycin to induce DNA lesions and inhibit homologous recombination to greatly enhance the effect of radiotherapy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Neutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

This study evaluated for a multifactor structure in the DASS-21 teenagers and the specifics of the 3 subscales for teenagers in general at different stages. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

A novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Policy Context Indicator Information View the Maps Individuals are classified as unemployed if they have not worked more than one hour in the ...

• Western Australian Child Development Atlas
• CDA Indicators

Project D-Light aims to understand and harness the benefits of vitamin D and sunlight for Australian children while protecting them from excess UV. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2014
• March

Disruptions of malaria case management caused by the COVID-19 pandemic likely contributed to an extra 76,000 malaria deaths in sub-Saharan Africa, according to analysis by Telethon Kids Institute and Curtin University. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2023
• June

Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Visceral leishmaniasis (VL; Leishmania donovani) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10, a cytokine implicated in VL, on this response. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Early changes in cell morphology upon treatments are a strong indication that the inhibitor is directly targeting tubulin ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018