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        Research

        Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic

        Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare. ...

        Research

        Association between male genital anomalies and adult male reproductive disorders: a population-based data linkage study spanning more than 40 years

        Undescended testes is associated with an increased risk of testicular cancer and male infertility, and decreased paternity ...

        Research

        Accumulation of CD103+ CD8+ T cells in a cutaneous melanoma micrometastasis

        Results support the emerging concept that CD103+ CD8+ tissue‐resident memory T cells are key mediators of cancer surveillance ...

        Sarcoma Translational Research

        We think all kids with Sarcoma should be able to lead happy, healthy lives! To achieve this, we aim to discover and develop safer and more effective treatments by doing inventive and rigorous research. We focus on addressing high relapse rates using a combination of unique pre-clinical models, patient samples and systems immunology. ...

        Research

        Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells

        Human embryonic stem cell-derived neural stem cells (hESC-NSCs) are an attractive cell type for studying ...

        News & Events

        “Natural killer” donor cells fighting kids leukaemia

        New research by Telethon Kids shows donor immune cells are highly effective at boosting the body’s response against leukaemia. ...

        Research

        Parental occupational exposure to engine exhausts and childhood brain tumors

        Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. ...

        Research

        An Anti-VEGF-B Antibody Reduces Abnormal Tumor Vasculature and Enhances the Effects of Chemotherapy

        The vascular endothelial growth factors and their receptors are key regulators of blood vessel formation, including in tumors, where their deregulated function can promote the production of aberrant, leaky blood vessels, supporting tumor development.  ...

        Research

        Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether Ionophore

        Our findings highlight the potential of salinomycin to induce DNA lesions and inhibit homologous recombination to greatly enhance the effect of radiotherapy ...

        Research

        Clinical Trials in the Brain Tumour Population: Challenges and Strategies for the Future

        This review identifies challenges and barriers to successful development of drugs in neuro-oncology trials at the preclinical, clinical and translational stages that we believe has contributed to poor outcomes for patients over the last 30 years. ...

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