Successful defence against viral pathogens requires the rapid recognition of virus-specific "danger signals" and the activation of both innate and adaptive... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• September 2011

As part of the accelerated development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we report a dose-finding and adjuvant justification study of SCB-2019, a protein subunit vaccine candidate containing a stabilised trimeric form of the spike (S)-protein (S-Trimer) combined with two different adjuvants. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Maternal immunization with pneumococcal conjugate vaccine (PCV) may protect young infants in high-risk settings against the high risk of pneumococcal infections in early life. The aim of this study was to determine the safety and immunogenicity of 13-valent PCV (PCV13) in healthy women of childbearing age in PNG. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberculosis, HIV, respiratory syncytial virus, and other major infections of global significance. Approaches at rational vaccine design have been limited by our understanding of the immune response to vaccination at the molecular level. Tools now exist to undertake in-depth analysis using systems biology approaches, but to be fully realized, studies are required in humans with intensive blood and tissue sampling. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

Overall, the 2016 influenza vaccine showed good protection against laboratory-confirmed infection among general practice patients ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• May 2019

Our population-based cohort study demonstrates that >90% coverage in the first year of a universal 3 + 0 PCV program provided high population-level protection ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

Immune responses after the initial vaccination persisted for the 12 months studied, with little additional response after the booster dose at 6 months ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• November 2016

There is limited empiric evidence on the coverage of pneumococcal conjugate vaccines (PCVs) required to generate substantial indirect protection. We investigate the association between population PCV coverage and indirect protection against invasive pneumococcal disease (IPD) and pneumonia hospitalisations among undervaccinated Australian children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

AusVaxSafety surveillance demonstrated comparable and expected safety outcomes for the 2017 quadrivalent inactivated influenza vaccine brands used in Australia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

We explored midwives' attitudes and values regarding maternal and childhood vaccination, their perceived role in vaccine advocacy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019