Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

These findings reinforce current recommendations for annual influenza vaccination, particularly those at greatest risk of influenza disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• June 2017

The efficacy of the human papillomavirus type 16 (HPV-16)/HPV-18 AS04-adjuvanted vaccine against cervical infections with HPV... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

We still do not have a RF vaccine, although the recent announcement that the Australian and New Zealand governments are jointly sponsoring a program to fast... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• September 2013

Invasive pneumococcal disease (IPD) continues to occur at high rates among Australian Aboriginal people. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• December 2013

We conducted an open randomized controlled trial in Papua New Guinea to compare safety, immunogenicity and priming for memory of 7-valent PCV (PCV7) given in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Bacterial conjugate vaccines are based on the principle of coupling immunogenic bacterial capsular polysaccharides to a carrier protein to facilitate the... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Despite an effective vaccine, measles remains a major health problem globally, particularly in developing countries. More than 30% of children show primary... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

This methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012