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        Research

        Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys

        Population-level ecological studies show type 1 diabetes incidence is inversely correlated with ambient ultraviolet radiation (UVR) levels. We conducted a nested case–control study using administrative datasets to test this association at the individual level. ...

        Research

        Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision

        To compare meal-time glycaemia in adults with type 1 diabetes mellitus managed with multiple daily injections vs. insulin pump therapy, using self-monitoring blood glucose, following diabetes education. ...

        Research

        Peri-operative steroid management in the paediatric population

        Patients with adrenal insufficiency are at risk of adrenal crisis, a potentially life-threatening emergency in the peri-operative period due to their attenuated ability to mount a cortisol response. ...

        Research

        Advances in Exercise and Nutrition as Therapy in Diabetes

        We surveyed 2200 potentially eligible titles on PubMed and other common search engines for manuscripts on “exercise, nutrition, and diabetes” published between July 1, 2019, and June 30, 2020. This year's articles tended to focus on testing new applications for exercise management, including new insulin treatment approaches, wearables, and new smartphone applications. ...

        Research

        Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium

        Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. ...

        Research

        Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

        We demonstrate a distinct gut virome profile in infants of mothers with type 1 diabetes, which may influence health outcomes later in life ...

        Research

        Advances in Exercise, Physical Activity, and Diabetes

        We screened more than 750 potentially eligible titles on PubMed and other common search engines for manuscripts on “exercise and diabetes” ...

        Research

        Improvement in Psychosocial Outcomes in Children with Type 1 Diabetes and Their Parents Following Subsidy for Continuous Glucose Monitoring

        Introduction of subsidized CGM showed early improvement in psychosocial and glycemic outcomes in patients and their families in Western Australia ...

        Research

        Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

        We find that DNA methylation in neonatal blood is associated with birthweight, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation ...

        Research

        Comprehensive genetic screening: The prevalence of maturity-onset diabetes of the young gene variants in a population-based childhood diabetes cohort

        This is the first comprehensive study of maturity-onset diabetes of the young variants in an unselected population-based pediatric diabetes cohort ...

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