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        21-30 of 115 results for 'alexander larcombe'

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        Research

        Long-term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and elicits hyperactive behaviours in young adulthood

        Atmospheric carbon dioxide (CO2) levels are currently at 418 parts per million (ppm), and by 2100 may exceed 900 ppm. The biological effects of lifetime exposure to CO2 at these levels is unknown. Previously we have shown that mouse lung function is altered by long-term exposure to 890 ppm CO2. Here, we assess the broader systemic physiological responses to this exposure. ...

        Research

        Confounding effects of gavage in mice: Impaired respiratory structure and function

        It is therefore clear that gavage can have significant impacts on experimental animals in terms of their stress response and overall morbidity and mortality ...

        Research

        In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice

        All alterations to lung mechanics following in utero arsenic exposure were recovered by adulthood. ...

        Research

        Respiratory toxicology of e-cigarettes: effect of vapours on lung function and inflammation

        Electronic cigarettes (ECs) have been rapidly gaining ground on conventional cigarettes due to their efficiency in ceasing or reducing tobacco consumption,... ...

        Research

        Soy Biodiesel Exhaust is More Toxic than Mineral Diesel Exhaust in Primary Human Airway Epithelial Cells

        Exposure to biodiesel exhaust resulted in significantly greater cell death and a greater release of immune mediators compared to both air controls and ULSD exhaust ...

        Research

        Chronic carbon dioxide exposure: an unrecognised health risk of climate change?

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        Computational fluid-particle dynamic and pharmacokinetic assessment of electronic cigarette aerosols for improved understanding of their potential to impact health

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate ...

        Research

        Development of a screening tool to identify safer biodiesels

        Alexander Anthony Larcombe Kicic A A BScEnv (Hons) PhD BSc (Hons) PhD Team Leader, Respiratory Environmental Health Rothwell Family Fellow; Head, ...

        Research

        Editorial overview: Endocrine and metabolic adaptations to extreme environments: Living life to the extreme – insights into the limits of life and transitions to disease

        The need to understand responses to extreme environments has prompted this edition of Current Opinion in Endocrine and Metabolic Research ...

        Research

        The effects of acamprosate on maternal and neonatal outcomes in a mouse model of alcohol use disorders

        Despite the teratogenic effects of alcohol, little is known about the safety of pharmacotherapies such as acamprosate for the treatment of alcohol use disorders in pregnancy. The aims of this study were to investigate, in a mouse model, the effects of maternally administered acamprosate on maternal and neonatal health, offspring neurodevelopment and behaviour, as well as examine whether acamprosate reduces the neurological harm associated with alcohol consumption in pregnancy. ...

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