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        Research

        Bronchial brushings for investigating airway inflammation and remodelling

        Asthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable... ...

        News & Events

        Directing immune development to curb sky-rocketing disease

        Once upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism. ...

        News & Events

        Annual Community Lecture: You Are What You Breathe

        Join us for our Annual Community Lecture entitled "You Are What You Breathe" with Professor Stephen Holgate. ...

        Research

        DEFEND CF: Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosis

        Stephen Graham Stick Hall SM GL MB BChir PhD MRCP FRACP BAppSci PhD CRFS FANZSRS FThorSoc FERS Head, P4 Respiratory Health for Kids Honorary Research ...

        Research

        Differential cell counts using center-point networks achieves human-level accuracy and efficiency over segmentation

        Differential cell counts is a challenging task when applying computer vision algorithms to pathology. Existing approaches to train cell recognition require high availability of multi-class segmentation and/or bounding box annotations and suffer in performance when objects are tightly clustered. ...

        Research

        Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

        Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure ...

        Research

        The plural of anecdote is not data, please mind the gap

        The COVID-19 pandemic introduced challenges to everyone in society but particularly so to every aspect of medical practice. It is bewildering how quickly the profession has had to respond to rapidly changing clinical landscape. Our well-established methods involve collecting and analyzing data to generate an evidence base which is then disseminated and implemented into routine clinical practice. ...

        Research

        Acute haemoptysis, fever and abdominal pain in an adolescent from northern Australia

        Christopher Asha André Dr Anita Blyth Bowen Schultz Campbell CC AC AS AC MBBS (Hons) DCH FRACP FRCPA PhD BA MBBS DCH FRACP PhD GAICD OAM MBChB, PhD, ...

        Research

        Epithelial Mesenchymal Transition in Respiratory Disease: Fact or Fiction

        In this translational review, the mechanisms, roles, and impact of epithelial-mesenchymal transition in chronic lung diseases are discussed ...

        Research

        Role of Tris-CaEDTA as an adjuvant with nebulised tobramycin in cystic fibrosis patients with Pseudomonas aeruginosa lung infections: A randomised controlled trial

        We tested if disrupting iron utilisation by P. aeruginosa by adding the Tris-buffered chelating agent CaEDTA to nebulised tobramycin would enhance bacterial clearance and improve lung function in CF patients. ...

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