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        PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

        Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. ...

        Research

        Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

        Here, we demonstrate that group A Streptococcus (GAS) utilises Mn(II) import via MtsABC during conditions of hydrogen peroxide stress ...

        Research

        Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

        This paper demonstrated that home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. ...

        Research

        Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium

        In this investigation, the authors found an association between home pesticide exposure before birth and during a child's early years and acute lymphoblastic... ...

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        Novel CT domain-encoding splice forms of CTGF/CCN2 are expressed in B-lineage acute lymphoblastic leukaemia

        Connective tissue growth factor (CTGF/CCN2) has been shown previously to be aberrantly expressed in a high proportion of paediatric precursor B cell acute... ...

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        Participation in population-based case-control studies: does the observed decline vary by socio-economic status?

        Participation in population-based case-control studies: does the observed decline vary by socio-economic status? ...

        Research

        Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia

        The association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated ...

        Research

        Familial aggregation of childhood and adult cancer in the Utah genealogy

        We explored familial aggregation of cancer in a population-based case-control study using genealogical record linkage and designed to overcome limitations of... ...

        Healthy Lungs & Immune Development

        Discover. Prevent. Cure. Healthy Lungs & Immune Development Focusing on the developmental trajectories of respiratory health includes developing ...

        Research

        Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

        Streptococcus dysgalactiae subspecies equisimilis and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer possibly underlying shared disease phenotypes. ...

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