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        Research

        Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

        Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. ...

        Research

        AMEND study protocol: A case-control study to assess the long-term impact of invasive meningococcal disease in Australian adolescents and young adults

        This study aims to address this evidence gap by assessing the clinical, physical, neurocognitive, economic and societal impact of invasive meningococcal disease ...

        Research

        Prevalence of chronic wet cough and protracted bacterial bronchitis in aboriginal children

        Strategies to address reasons for and treatment of chronic wet cough and protracted bacterial bronchitis in young Aboriginal children in remote north Western Australia are required ...

        Research

        Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients

        Our data illustrate that rhinovirus infection is capable of infecting upper and lower airway epithelial cells, driving cell death and inflammation ...

        Research

        Confounding effects of gavage in mice: Impaired respiratory structure and function

        It is therefore clear that gavage can have significant impacts on experimental animals in terms of their stress response and overall morbidity and mortality ...

        Research

        Sun-immune connection

        Exposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system ...

        Research

        Availability and administration of benzathine penicillin G for the prevention of rheumatic fever in Africa: Report of the Working Group on Penicillin

        Benzathine penicillin G availability should be addressed and African health workers’ knowledge and practices need to be augmented ...

        Research

        Paediatric asylum seekers in Western Australia: Identification of adversity and complex needs through comprehensive refugee health assessment

        Paediatric asylum seekers have complex trauma backgrounds with exposure to multiple adverse events within disrupted family units ...

        Research

        Impact of multidrug-resistant tuberculosis and its medications on adverse maternal and perinatal outcomes: Protocol for a systematic review and meta-Analysis

        We aim to determine whether multidrug-resistant tuberculosis and its medications during pregnancy impact maternal and perinatal outcomes ...

        Research

        Corynebacterium and Dolosigranulum: Future probiotic candidates for upper respiratory tract infections

        We recently identified C. pseudodiphtheriticum and D. pigrum as the major nasopharyngeal species associated with resistance to recurrent ear infections ...

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