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        301-310 of 1005 results for 'CANCER'

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        Research

        ErbB4 in the brain: Focus on high grade glioma

        The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTKs) consists of EGFR, ErbB2, ErbB3, and ErbB4. These receptors play key roles in cell proliferation, angiogenesis, cell migration, and in some cases, tumor promotion. ...

        Research

        Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

        Cancer immunotherapy has shown impressive results, but most patients do not respond. ...

        Research

        Setonix Pharmaceuticals: Enhancing immuno-oncology with small molecule drugs

        Team Associate Professor W. Joost Lesterhuis Director Email Associate Professor Matt Piggott Director Email Dr Alma Fulurija Director Email Dr Louis ...

        Research

        Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic

        Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare. ...

        Research

        Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

        Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained ...

        Research

        Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

        The functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target ...

        Research

        Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines

        Glucocorticoids (GCs) are among the most important drugs for the treatment of acute lymphoblastic leukaemia (ALL). ...

        People

        Professor Nick Gottardo

        Co-Head, Brain Tumour Research ...

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        Research

        Developing and characterising juvenile models of aggressive paediatric brain cancers for the evaluation of novel immunotherapies.

        Raelene Nick Jessica Annabel Meegan Jacqueline Endersby Golding Buck Short Howlett Whitehouse R NG JB AS MH JW BSc (Hons) PhD BSc DPhil DPhil BMedRes ...

        Research

        Drug-gene modeling in pediatric T-cell acute lymphoblastic leukemia highlights importance of 6-mercaptopurine for outcome

        This study advances our understanding of drug resistance in T-ALL and provides new markers for patient stratification. ...

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