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        Research

        Population and Public Health Perspectives on Late Language Emergence at 24 Months as a Risk Indicator for Language Impairment at 7 Years

        The emergence of language during the toddler period is one of the most striking accomplishments in young children's development. ...

        Research

        Multiple-breath washout as a lung function test in cystic fibrosis: A cystic fibrosis foundation workshop report

        Recent technological advances in equipment design have produced gains in popularity for this test among cystic fibrosis (CF) researchers and clinicians... ...

        Research

        Resilience amongst Australian Aboriginal youth: An ecological analysis of factors associated with psychosocial functioning

        We investigate whether the profile of factors protecting psychosocial functioning of high risk exposed Australian Aboriginal youth are the same as those... ...

        Research

        CRISPR-Cas9-generated PTCHD1 2489T>G stem cells recapitulate patient phenotype when undergoing neural induction

        An estimated 3.5%-5.9% of the global population live with rare diseases, and approximately 80% of these diseases have a genetic cause. Rare genetic diseases are difficult to diagnose, with some affected individuals experiencing diagnostic delays of 5-30 years. Next-generation sequencing has improved clinical diagnostic rates to 33%-48%. In a majority of cases, novel variants potentially causing the disease are discovered.  ...

        Research

        Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

        High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and tolerability of chemotherapy. However, enhancements in drug efficacy have been limited because of a lack of selectivity of the liposomal formulations for the cancer cells. ...

        Research

        Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli

        We obtain a set of 57 candidate immediate early genes possessing promoters that consistently drive a rapid but transient increase in expression over time ...

        Research

        Are scabies and impetigo “normalised”? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition

        Scabies and impetigo infections are under-recognised and hence under-treated by clinicians ...

        Research

        Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage

        This study helps us understand how cancer cells are regulated by key genes and their corresponding networks to alter their fate in response to specific... ...

        News & Events

        Long-term Telethon Kids Institute researchers honoured by prestigious Academy

        Professors Carol Bower & Steve Zubrick have been inducted as new Fellows to the prestigious Australian Academy of Health and Medical Sciences. ...

        News & Events

        Study shows the value of positive friends for Aboriginal kids

        A new study has found that having a friend with good social skills and a supportive family may make a critical difference to the resilience of Aboriginal youth ...

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