Raelene Nick Endersby Gottardo R NG BSc (Hons) PhD MBChB FRACP PhD Brainchild Fellow; Co-Head, Brain Tumour Research Co-Head, Brain Tumour Research ...

• Telethon Kids Institute
• Projects

What is Down syndrome? What is leukaemia? Dr Rishi Kotecha, Dr Laurence Cheung and Dr Sébastien Malinge Kids born with Down syndrome are at high risk ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2020
• In the pipeline

Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Bioinformatician ...

• Telethon Kids Institute
• Contact us
• Our people
• Staff Profiles - P

Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

The Translational Genomics in Leukaemia team is focused on identifying the causes of leukaemia, with the goal of developing new targeted treatments to improve quality of care and long-term survival for all children with leukaemia. ...

• Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Cancer Program

The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014