Raelene Nick Endersby Gottardo R NG BSc (Hons) PhD MBChB FRACP PhD Brainchild Fellow; Co-Head, Brain Tumour Research Co-Head, Brain Tumour Research ...

• 1. Telethon Kids Institute
• Projects

Team Associate Professor W. Joost Lesterhuis Director Email Associate Professor Matt Piggott Director Email Dr Alma Fulurija Director Email Dr Louis ...

• 1. Telethon Kids Institute
• Projects

The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTKs) consists of EGFR, ErbB2, ErbB3, and ErbB4. These receptors play key roles in cell proliferation, angiogenesis, cell migration, and in some cases, tumor promotion. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

Cancer immunotherapy has shown impressive results, but most patients do not respond. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

The main issues that led to the ban on asbestos in industry are those of malignancy: lung cancer, malignant mesothelioma of the pleura and of the peritoneum ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

What is Down syndrome? What is leukaemia? Dr Rishi Kotecha, Dr Laurence Cheung and Dr Sébastien Malinge Kids born with Down syndrome are at high risk ...

• 1. Telethon Kids Institute
• Our research
• Research Impact
• 2020
• In the pipeline