Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system that results in demyelination of axons, inefficient signal transmission and reduced muscular mobility. Recent findings suggest that B cells play a significant role in disease development and pathology. To further explore this, B cell profiles in peripheral blood from 28 treatment-naive patients with early MS were assessed using flow cytometry and compared to 17 healthy controls. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Pat Belinda Holt Hales PG BJ PhD, DSc, FRCPath, FRCPI, FAA BSc (Hons) PhD Emeritus Honorary Researcher Senior Manager, Research Platforms ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• September 2010

This chapter describes the preparation of respiratory tract tissue from both mice and rats for the isolation of respiratory tract dendritic cells (RTDC). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

A significant proportion of chronic obstructive pulmonary disease exacerbations are strongly associated with rhinovirus infection (HRV). In this study, we combined long-term cigarette smoke exposure with HRV infection in a mouse model. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Atopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date combining previously reported cohorts with additional available data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG on the development of early‐onset atopic dermatitis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• February 2015

There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• June 2012

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• December 2012

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011