This study suggests that germ-line DICER1 mutations make a clinically significant contribution to PinB, establishing DICER1 as an important susceptibility... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

RNA-sequencing (RNA-seq) efforts in acute lymphoblastic leukaemia have identified numerous prognostically significant genomic alterations which can guide diagnostic risk stratification and treatment choices when detected early. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

Unlike adults, malignant melanoma in children and adolescents is rare. In adult melanoma, significant progress in understanding tumor biology and new treatments, including targeted therapies and immunotherapy have markedly improved overall survival. In sharp contrast, there is a paucity of data on the biology and clinical behavior of pediatric melanoma. We report a national case series of all pediatric and adolescent malignant melanoma presenting to ANZCHOG Childhood Cancer Centers in Australia and New Zealand. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Here we describe 19 new cases with RASopathy due to disease-causing variants in NRAS ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• June 2017

Full time 2 years with the possibility of extension Studying Biology at single-cell resolution is set to revolutionize our understanding of human ...

• 1. Telethon Kids Institute
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• Careers and Volunteering
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This study advances our understanding of drug resistance in T-ALL and provides new markers for patient stratification. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Acute lymphoblastic leukemia and childhood brain tumors are 2 of the most common forms of childhood cancer, but little is known of their etiology. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• November 2023

ZFTA-RELA (formerly known as c11orf-RELA) fused supratentorial ependymoma has been recognized as a novel entity in the 2016 WHO classification of CNS tumors and further defined in the recent 2021 edition. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023