Diffuse intrinsic pontine gliomas generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

This study contributes to our understanding of the genetic diversity of NMC, an important step towards finding therapeutic targets for a disease that is... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• November 2012

Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and establishing leukemia-supportive interactions with stromal and immune cells. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Here we present an approach for the DNA methylation-based classification of central nervous system tumors across all groups and demonstrate its application. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

One of Australia’s leading cancer research centres continues to be powered by parents who decided to fight back. Hard. ...

• Giving at Telethon Kids
• Your impact
• Giving stories
• Stories from our Community
• 2017

The Aussie summer provides some great opportunities for families to connect in an active and social way. But with it comes a range of factors that can impact on child and family health. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2019
• December

The main issues that led to the ban on asbestos in industry are those of malignancy: lung cancer, malignant mesothelioma of the pleura and of the peritoneum ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021