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        Research

        Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis

        Our findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Early life innate immune signatures of persistent food allergy

        Early life innate immune dysfunction may represent a key immunological driver and predictor of persistent food allergy in childhood ...

        Research

        Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood

        Lung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period ...

        Research

        The impact of respiratory viruses on lung health after preterm birth

        The aim of this review is to highlight the risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants ...

        Research

        Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targeting

        This review concentrates on the phosphoethanolamine decoration of lipid A in the pathogenic species of the genus Neisseria ...

        Research

        Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis

        Higher IDO and ARG expression in clinically isolated syndrome and multiple sclerosis provides one sustained homeostatic mechanism to control multiple sclerosis-associated inflammation ...

        Research

        Cochrane corner: hearing aids for mild to moderate hearing loss in adults

        The evidence supports the widespread provision of hearing aids as the first-line clinical management for those seeking help for hearing difficulties ...

        Research

        Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome

        IgG3 levels and proportions of IgG3 (%IgG) in serum at CIS diagnosis were inversely correlated with the time until conversion to MS ...

        Research

        Cardiometabolic risk factors at 5 years after omega-3 fatty acid supplementation in infancy

        Supplementation with n-3 LCPUFA in infancy revealed a reduction in waist circumference at 5 years ...

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