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        Research

        Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

        Infants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL. ...

        Research

        Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy

        Infants with KMT2A-rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes have remained static in recent decades despite treatment intensification and novel therapies are urgently required. ...

        Research

        Young Minds Matter

        Steve Sarah Zubrick Johnson SR SJ FASSA, FAAMHS, MSc AM PhD BA, PostGradDip; PhD Honorary Emeritus Research Fellow Senior Research Fellow 08 6319 ...

        Research

        Assessing the protective effect of influenza vaccine against laboratory confirmed influenza in hospitalised children aged 6-59 months

        Influenza vaccine was offered to all children aged 6-59 months resident in Western Australia in 2008, and we wished to evaluate the effectiveness of this immunisation programme. ...

        Research

        Epigenetics in infectious diseases

        Viruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts. ...

        Research

        Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication

        We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols to determine... ...

        Research

        Influenza vaccine effectiveness against laboratory-confirmed influenza in healthy children aged 6-59 months:

        The Western Australian Influenza Vaccine Effectiveness study commenced in 2008 to evaluate a new program to provide free influenza vaccine to all children... ...

        Research

        Meningiomas in children and adolescents: a meta-analysis of individual patient data

        The epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined... ...

        Research

        Maximising fathers’ roles in preventing adolescent alcohol-related harm. (Fathers and Adolescent Alcohol Use Project)

        Robyn Karen Gina Karen Johnston Lombardi Trapp Forde RJ KL GT KF BSc, Post Grad Dip, PhD BHSc (Hons), PhD BHSc(Hons1A), RPHNutr, PhD BHlthSc (Hons 1A ...

        News & Events

        Children with disabilities 3 times more likely to be maltreated but risk varies by disability type

        A new study has found children with disabilities are 3 times more likely to be maltreated compared to other children but that risk varies by type of disability. ...

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