Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2024
• April 2024

PhD student ...

• 1. Telethon Kids Institute
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These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2019
• June 2019

Bioinformatician ...

• 1. Telethon Kids Institute
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The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

• 1. Telethon Kids Institute
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• 2021
• September 2021

We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

• 1. Telethon Kids Institute
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• 2019
• April 2019

With improvement in leukemia therapy, central nervous system (CNS) tumors are the leading cause of cancer mortality in children and the most expensive... ...

• 1. Telethon Kids Institute
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• 2011
• January 2011

Postdoctoral Research Fellow ...

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The search for novel microRNA (miRNA) biomarkers in plasma is hampered by haemolysis, the lysis and subsequent release of red blood cell contents, including miRNAs, into surrounding fluid. The biomarker potential of miRNAs comes in part from their multicompartment origin and the long-lived nature of miRNA transcripts in plasma, giving researchers a functional window for tissues that are otherwise difficult or disadvantageous to sample. ...

• 1. Telethon Kids Institute
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• 2023
• February 2023

Our study provides evidence that OT-82 is a promising new therapeutic strategy for a broad spectrum of high-risk pediatric acute lymphoblastic leukemia ...

• 1. Telethon Kids Institute
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• 2020
• June 2020